New infectious diseases have been identified as important security risks for the U.S. Recently, global public health security has been mentioned in the media, with increased concern about diseases like Zika, Ebola, and others. International responses to disease outbreaks have provided global benefits. This seven-session course will review the risks from new and emerging infectious diseases, within the context of Global Public Health realities, and the status of surveillance and response systems. We will discuss the experiences with the responses to SARS (Severe Acute Respiratory Syndrome) and Ebola Virus Disease outbreaks, with a focus on public health aspects, and also conduct a simulation exercise responding to a rapidly developing outbreak of a previously unknown disease. In addition, the public health, management and cross-cultural aspects of the successful smallpox eradication effort and the ongoing polio eradication initiative will be reviewed. The format for the course will be PowerPoint presentations, videos, class discussions, a guest speaker, and a simulation exercise. Links to selected articles will be provided, as well as a reading list.